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Repurposing calcium channel blockers as antiviral drugs.
Journal of Cell Communication and Signaling ( IF 3.6 ) Pub Date : 2020-08-19 , DOI: 10.1007/s12079-020-00579-y
Vijayashree Priyadharsini Jayaseelan 1 , Arumugam Paramasivam 1
Affiliation  

The current pandemic caused by the SARS-CoV-2 has claimed over a half a million lives within a very short span of time. A therapeutic drug which could prevent the entry and propagation of the virus is the need of the hour. Several lines of evidence collected from experimental studies older than three decades have pointed out the fact that inhibiting calcium entry into cells can affect vital steps in the lifecycle of viruses. Hence, calcium channel blockers may be considered as an effective measure in the containment of the viruses. This commentary throws light two scientific papers although with divergent facts converging at a point by suggesting a promising treatment option for CoVID-19 (Fang et al. Lancet Respir Med 8:e21, 2020; Straus et al. J Virol 94:e00426, 2020).



中文翻译:

重新使用钙通道阻滞剂作为抗病毒药。

由SARS-CoV-2引起的当前大流行在很短的时间内夺走了50万条生命。可能需要一小时的时间来防止病毒进入和传播的治疗药物。从超过三十年的实验研究中收集到的证据表明,抑制钙进入细胞可以影响病毒生命周期的关键步骤。因此,钙通道阻滞剂可以被认为是控制病毒的有效措施。这篇评论提出了两篇科学论文,尽管通过提出CoVID-19的有希望的治疗选择在一个点上存在着分歧的事实(Fang等人,《柳叶刀》 Respir Med 8:e21,2020; Straus等人,J Virol 94:e00426,2020) )。

更新日期:2020-08-20
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