Deletions of chromosome 1p36 are common in malignancies; however, there is limited information regarding the biological and prognostic implications of 1p36 in cancer. Steroid Receptor–Associated and Regulated Protein (SRARP) is a tumor suppressor on chromosome 1p36.13 that its inactivation predicts poor cancer outcome, indicating that the 1p36.13 segment requires further studies. Therefore, a comprehensive multi-omics analysis of The Cancer Genome Atlas (TCGA), the Pan-Cancer Analysis of Whole Genomes (PCAWD), the International Cancer Genome Consortium (ICGC), and the Genomic Data Commons (GDC) Pan-Cancer datasets was conducted to investigate the prognostic implications of 1p36.13 in malignancies. This study revealed that expression and DNA methylation of multiple genes on 1p36.13 are significantly associated with survival in primary tumors and normal adjacent tissues. In addition, copy-number loss in every gene on 1p36.13 predicts poor cancer outcome. Importantly, copy-number loss and somatic mutations of chromosome 1p36.13 segment are associated with worse survival in primary tumors, and DNA hypermethylation of 1p36.13 predicts poor outcome in normal adjacent tissues. Therefore, genomic and epigenetic aberrations of chromosome 1p36.13 have promising prognostic implications in cancer.

1p36 染色体缺失在恶性肿瘤中很常见；然而，关于 1p36 在癌症中的生物学和预后意义的信息有限。类固醇受体相关和调节蛋白 (SRARP) 是染色体 1p36.13 上的肿瘤抑制因子，其失活预示着癌症预后不佳，表明 1p36.13 片段需要进一步研究。因此，对癌症基因组图谱 (TCGA)、全基因组泛癌分析 (PCAWD)、国际癌症基因组联盟 (ICGC) 和基因组数据共享 (GDC) 泛癌数据集进行了全面的多组学分析进行了研究 1p36.13 在恶性肿瘤中的预后意义。该研究揭示了 1p36.1 上多个基因的表达和 DNA 甲基化。13 与原发性肿瘤和正常邻近组织的存活率显着相关。此外，1p36.13 上每个基因的拷贝数丢失预示着癌症预后不佳。重要的是，染色体 1p36.13 片段的拷贝数丢失和体细胞突变与原发性肿瘤的较差生存相关，1p36.13 的 DNA 高甲基化预示着正常邻近组织的不良预后。因此，染色体 1p36.13 的基因组和表观遗传畸变在癌症中具有有希望的预后意义。