Intracranial aneurysms frequently develop blood clots, plaque and inflammations, which are linked to enhanced particulate mass deposition. In this work, we propose a computational model for particulate deposition, that accounts for the influence of field forces, such as gravity and electrostatics, which produce an additional flux of particles perpendicular to the fluid motion and towards the wall. This field-mediated flux can significantly enhance particle deposition in low-shear environments, such as in aneurysm cavities. Experimental investigation of particle deposition patterns in in vitro models of side aneurysms, demonstrated the ability of the model to predict enhanced particle adhesion at these sites. Our results showed a significant influence of gravity and electrostatic forces (greater than 10%), indicating that the additional terms presented in our models may be necessary for modelling a wide range of physiological flow conditions and not only for ultra-low shear regions. Spatial differences between the computational model and the experimental results suggested that additional transport and fluidic mechanisms affect the deposition pattern within aneurysms. Taken together, the presented findings may enhance our understanding of pathological deposition processes at cardiovascular disease sites, and facilitate rational design and optimization of cardiovascular particulate drug carriers.

中文翻译：

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脑侧动脉瘤颗粒物沉积的计算与实验研究

颅内动脉瘤经常形成血栓、斑块和炎症，这与颗粒物质沉积增强有关。在这项工作中，我们提出了颗粒沉积的计算模型，该模型考虑了场力的影响，例如重力和静电力，这些力会产生垂直于流体运动并朝向壁面的额外颗粒通量。这种场介导的通量可以显着增强低剪切环境中的颗粒沉积，例如在动脉瘤腔中。侧动脉瘤体外模型中颗粒沉积模式的实验研究表明，该模型能够预测这些部位的颗粒粘附增强。我们的结果显示重力和静电力的显着影响（大于 10%），表明我们模型中出现的附加项对于模拟广泛的生理流动条件可能是必要的，而不仅仅是超低剪切区域。计算模型和实验结果之间的空间差异表明额外的运输和流体机制影响动脉瘤内的沉积模式。综上所述，所提出的发现可能会增强我们对心血管疾病部位病理沉积过程的理解，并促进心血管颗粒药物载体的合理设计和优化。计算模型和实验结果之间的空间差异表明额外的运输和流体机制影响动脉瘤内的沉积模式。综上所述，所提出的发现可能会增强我们对心血管疾病部位病理沉积过程的理解，并促进心血管颗粒药物载体的合理设计和优化。计算模型和实验结果之间的空间差异表明额外的运输和流体机制影响动脉瘤内的沉积模式。综上所述，所提出的发现可能会增强我们对心血管疾病部位病理沉积过程的理解，并促进心血管颗粒药物载体的合理设计和优化。