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Spiromyrrhenes A–D: unprecedented diterpene–sesquiterpene heterodimers as intermolecular [4 + 2] cycloaddition products from Resina Commiphora that inhibit tumor stemness in esophageal cancer
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-19 , DOI: 10.1039/d0qo00656d
Bin-Yuan Hu 1, 2, 3, 4 , Shao-Xiang Wang 1, 2, 3, 4 , Yong-Ming Yan 1, 2, 3, 4 , Jia-Wang Liu 1, 2, 3, 4 , Da-Peng Qin 1, 2, 3, 4 , Yong-Xian Cheng 1, 2, 3, 4
Affiliation  

The structures and stereochemistry of spiromyrrhenes A–D (1–4), isolated from Commiphora exudates, were elucidated using NMR and ECD methods. They are the first examples of hepta- and octa-cyclic heterodimers possessing C35 skeletons, for the biosynthesis of which intermolecular [4 + 2] cycloaddition has been proposed. Biological studies show that they suppress tumor stemness in esophageal cancer by inactivating the Hippo/Yap pathway.

中文翻译:

螺旋藻AD:前所未有的二萜-倍半萜异二聚体,作为Resina Commiphora的分子间[4 + 2]环加成产物,可抑制食管癌中的肿瘤干

使用NMR和ECD方法阐明了从Commiphora渗出液中分离得到的螺旋藻A–D(1-4)的结构和立体化学。它们是具有C 35骨架的七环和八环异二聚体的第一个实例,已提出了其分子间[4 + 2]环加成的生物合成方法。生物学研究表明,它们通过灭活Hippo / Yap途径抑制食道癌中的肿瘤干。
更新日期:2020-09-16
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