Spiromyrrhenes A–D: unprecedented diterpene–sesquiterpene heterodimers as intermolecular [4 + 2] cycloaddition products from Resina Commiphora that inhibit tumor stemness in esophageal cancer,Organic Chemistry Frontiers

当前位置： X-MOL 学术 › Org. Chem. Front. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Spiromyrrhenes A–D: unprecedented diterpene–sesquiterpene heterodimers as intermolecular [4 + 2] cycloaddition products from Resina Commiphora that inhibit tumor stemness in esophageal cancer
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-19 , DOI: 10.1039/d0qo00656d
Bin-Yuan Hu _{1,

2,

3,

4} , Shao-Xiang Wang _{1,

2,

3,

4} , Yong-Ming Yan _{1,

2,

3,

4} , Jia-Wang Liu _{1,

2,

3,

4} , Da-Peng Qin _{1,

2,

3,

4} , Yong-Xian Cheng _{1,

2,

3,

4}

Affiliation

The structures and stereochemistry of spiromyrrhenes A–D (1–4), isolated from Commiphora exudates, were elucidated using NMR and ECD methods. They are the first examples of hepta- and octa-cyclic heterodimers possessing C₃₅ skeletons, for the biosynthesis of which intermolecular [4 + 2] cycloaddition has been proposed. Biological studies show that they suppress tumor stemness in esophageal cancer by inactivating the Hippo/Yap pathway.

中文翻译：

螺旋藻AD：前所未有的二萜-倍半萜异二聚体，作为Resina Commiphora的分子间[4 + 2]环加成产物，可抑制食管癌中的肿瘤干

使用NMR和ECD方法阐明了从Commiphora渗出液中分离得到的螺旋藻A–D（1-4）的结构和立体化学。它们是具有C ₃₅骨架的七环和八环异二聚体的第一个实例，已提出了其分子间[4 + 2]环加成的生物合成方法。生物学研究表明，它们通过灭活Hippo / Yap途径抑制食道癌中的肿瘤干。

更新日期：2020-09-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11