Revisiting the role of acids and hydrogen bond acceptors in enamine formation.,Organic & Biomolecular Chemistry

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Revisiting the role of acids and hydrogen bond acceptors in enamine formation.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-18 , DOI: 10.1039/d0ob01579b
Zhichao Lu ₁ , Gerald B Hammond , Bo Xu

Affiliation

A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported. Acids can accelerate the reaction but do not change the reaction equilibria. In comparison, hydrogen bond acceptors facilitate the enamine formation via their strong hydrogen bonding interaction with the water generated in the reaction.

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