Abstract: The furan nucleus is found in a large number of biologically active materials. In recent years, many natural furan derivatives were isolated and their biological effects were investigated. In this review, we focused on the anti-inflammatory and antimicrobial effects of some natural furans and discussed their effects on the immune system. Our investigation revealed that furan natural derivatives have effective antioxidant activities and exert regulatory effects on various cellular activities by modifying some signaling pathways such as MAPK (mitogen-activated Protein Kinase) and PPAR-ɣ (peroxisome proliferator-activated receptor gamma). The antimicrobial activity of these natural compounds was performed through selective inhibition of microbial growth and modification of enzymes. Further studies are needed for isolation and detection of different furan derivatives from natural compounds and investigation of their precise mechanisms for revealing health beneficial effects of these compounds.

Keywords: anti-inflammatory, antimicrobial, furans, benzofurans, furan natural derivatives


中文翻译：

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呋喃天然衍生物的抗炎和抗菌作用的最新进展。

摘要：呋喃核存在于大量生物活性物质中。近年来，分离了许多天然呋喃衍生物并研究了它们的生物学作用。在这篇综述中，我们重点研究了某些天然呋喃的抗炎和抗菌作用，并讨论了它们对免疫系统的影响。我们的研究表明，呋喃天然衍生物具有有效的抗氧化活性，并通过修饰某些信号通路（如MAPK（促分裂原激活的蛋白激酶）和PPAR-ɣ（过氧化物酶体增殖物激活的受体γ））对多种细胞活性发挥调节作用。这些天然化合物的抗菌活性是通过选择性抑制微生物生长和修饰酶来实现的。

关键词：抗炎，抗菌，呋喃，苯并呋喃，呋喃天然衍生物