Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes,Letters in Organic Chemistry

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Synthesis of C3-Quaternary 2H-Pyrrolines by [3+2] Cycloaddition of Isocyanoacetates and 1,1-Disubstituted Alkenes
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-07-31 , DOI: 10.2174/1570178617666191218104959
Yi Cheng ₁ , Runmei Zhang ₁ , Tianhao Lu ₁ , Yong Shen ₁ , Min Wang ₁ , Chunsong Xie ₁

Affiliation

Under mild conditions, C3-quaternary 2H-pyrrolines can be convergently and efficiently assembled by Cu(II) and weak bases cocatalyzed [3+2] cycloaddition of 1,1-disubstituted alkenes and isocyanoacetates. Various functionalities can be tolerated, affording 2H-pyrrolines with up to two quaternary centers in a single step.

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