Metal-Free Synthesis of Pyrimidinone Derivatives via Biginelli Reaction Using Aqueous NaICl2,Letters in Organic Chemistry

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Metal-Free Synthesis of Pyrimidinone Derivatives via Biginelli Reaction Using Aqueous NaICl2
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-07-31 , DOI: 10.2174/1570178617666191126095808
Navnath T. Hatvate ₁ , Shrikant M. Ghodse ₂ , Krishna N. Mundlod ₁ , Vikas N. Telvekar ₁

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Metal-free synthesis of pyrimidinone (alky/aryl) via Biginelli reaction in the presence of aqueous sodium dichloroiodate (NaICl2) was studied under reflux conditions. Herein, we first time report the synthesis of the aliphatic Biginelli product by using aliphatic aldehyde, cyclopentane, and urea. Several aromatic and heteroaromatic aldehydes were studied for the confirmation of the wide applicability of aq. NaICl2 for the synthesis of corresponding Biginelli products. The obtained desired products provide good to excellent yield.

中文翻译：

NaICl2水溶液通过Biginelli反应无金属合成嘧啶酮衍生物

在回流条件下，研究了在二氯碘酸钠水溶液（NaICl2）存在下通过Biginelli反应进行的无金属合成嘧啶酮（烷基/芳基）。本文中，我们首次报道了使用脂肪族醛，环戊烷和尿素合成脂肪族Biginelli产品的方法。对几种芳香族和杂芳香族醛进行了研究，以证实水溶液的广泛适用性。NaICl2用于合成相应的Biginelli产品。获得的所需产物提供良好至优异的产率。

更新日期：2020-07-31

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