A Simple Synthesis of the Anticancer Drug Altretamine,Letters in Organic Chemistry

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A Simple Synthesis of the Anticancer Drug Altretamine
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-07-31 , DOI: 10.2174/1570178617666200210111041
Vu Binh Duong ₁ , Pham Van Hien ₁ , Tran Thai Ngoc ₂ , Phan Dinh Chau ₂ , Tran Khac Vu ₂

Affiliation

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

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