Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or macrophage dysfunction plays a particularly significant role in asthma pathogenesis. Furthermore, crosstalk between them continuously transmits proinflammatory or anti-inflammatory signals, causing the immune cell activation or repression in the immune response. Consequently, the imbalanced immune microenvironment is the major cause of the exacerbation of asthma. Here, we discuss the role of T cells, macrophages, and their interactions in asthma pathogenesis.

中文翻译：

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T 细胞和巨噬细胞在哮喘发病机制中的作用：相互串扰的新视角。

哮喘与免疫细胞介导的先天性和适应性免疫有关。T 细胞或巨噬细胞功能障碍在哮喘发病机制中起着特别重要的作用。此外，它们之间的串扰不断传递促炎或抗炎信号，导致免疫细胞激活或抑制免疫反应。因此，不平衡的免疫微环境是哮喘恶化的主要原因。在这里，我们将讨论 T 细胞、巨噬细胞及其相互作用在哮喘发病机制中的作用。