The World Health Organization has called for new effective and affordable alternative antiviral materials for the prevention and treatment of viral infections. In this regard, calcium alginate has previously shown to possesses antiviral activity against the enveloped double-stranded DNA herpes simplex virus type 1. However, non-enveloped viruses are more resistant to inactivation than enveloped ones. Thus, the viral inhibition capacity of calcium alginate and the effect of adding a minuscule amount of carbon nanomaterials (0.1% w/w) have been explored here against a non-enveloped double-stranded DNA virus model for the first time. The results of this study showed that neat calcium alginate films are able to inactivate this type of non-enveloped virus and that including that extremely low percentage of carbon nanofibers significantly enhanced its viral inhibition from ~55.6% to 96.33%. This is the first published study to demonstrate CNFs antiviral activity. However, adding this small percentage of graphene oxide did not improve the antiviral activity of calcium alginate, although both composite biomaterials possess antiviral and other outstanding properties very promising for biomedical applications.

中文翻译：

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碳纳米纤维抗病毒活性的第一篇报道：海藻酸钙膜的病毒抑制能力增强

世界卫生组织呼吁为预防和治疗病毒感染寻求新的有效和负担得起的抗病毒替代材料。在这方面，藻酸钙先前已显示出对1型包膜的双链DNA疱疹病毒具有抗病毒活性。然而，非包膜的病毒比包膜的对包膜的病毒更具抗性。因此，在此首次针对非包膜的双链DNA病毒模型研究了藻酸钙的病毒抑制能力和添加微量碳纳米材料（0.1％w / w）的效果。这项研究的结果表明，纯净的海藻酸钙膜能够灭活这种非包膜病毒，其中包括极低百分比的碳纳米纤维，可将其病毒抑制率从约55.6％增强至96.33％。这是第一个发表的证明CNF抗病毒活性的研究。然而，尽管这两种复合生物材料都具有抗病毒和其他出色的特性，这对于生物医学应用来说非常有前景，但是添加少量的氧化石墨烯并不能提高藻酸钙的抗病毒活性。