Visualizing siRNA targeting of single mRNAs in living cells reveals that passing ribosomes temporarily unfold the mRNA, exposing it to siRNA recognition. This effect is due to the slow reorganization of many weak, suboptimal interactions within the mRNA.

中文翻译：

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核糖体为 siRNA 靶向扫清了道路。

将活细胞中单个 mRNA 的 siRNA 靶向可视化显示，通过核糖体时，mRNA 会暂时展开，使其暴露于 siRNA 识别中。这种效应是由于 mRNA 内许多弱的、次优的相互作用的缓慢重组。