ABSTRACT Acer tegmentosum (ATM) has antioxidant and anti-adipogenic activity. However, few studies have investigated the pharmacological activity or mechanism of ATM as an antidepressant agent. We assessed the antidepressant effect of ATM in modulating menopausal depressive symptoms and its mechanisms in ovariectomized (OVX) and repeatedly stressed (RS) female rats. The female rats were randomly divided into four groups: (1) naïve normal (normal) group, (2) OVX + repeated stress + saline-treated (control) group, (3) OVX + repeated stress + ATM (100 mg•kg−1)-treated (ATM100) group and (4) OVX + repeated stress + ATM (400 mg•kg−1)-treated (ATM400) group. We performed a battery of tests, such as the forced swimming test (FST), the sucrose intake test, and social exploration. After behavior testing, serum corticosterone levels were examined, followed by immunohistochemical determination of c-Fos, tyrosine hydroxylase (TH), and interleukin-1 beta (IL-1β) expression in the brain. ATM administration was associated with significantly decreased immobility time in the FST. Also, the control group tended to have decreased sucrose intake and social exploration compared with the normal group. However, ATM treatment was associated with markedly increased sucrose intake and active social exploration. In the paraventricular nucleus, c-Fos and IL-1β expression were significantly decreased in the ATM400 group compared with the control group. Compared with the control group, high-dose ATM administration was also associated with markedly decreased expression of TH-immunoreactive neurons in the locus coeruleus. The study findings demonstrated that ATM treatment effectively decreased behavioral and pathophysiological depression-like responses.

中文翻译：

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被覆槭对反复应激性去卵巢雌性大鼠的抗抑郁作用及神经机制

摘要 Acer tegmentosum (ATM) 具有抗氧化和抗脂肪生成活性。然而，很少有研究调查 ATM 作为抗抑郁药的药理活性或机制。我们评估了 ATM 在调节卵巢切除 (OVX) 和反复应激 (RS) 雌性大鼠更年期抑郁症状中的抗抑郁作用及其机制。雌性大鼠随机分为四组：（1）幼稚正常（正常）组，（2）OVX+重复应激+生理盐水处理（对照组），（3）OVX+重复应激+ATM（100mg•kg） -1)-治疗 (ATM100) 组和 (4) OVX + 重复应激 + ATM (400 mg•kg-1)-治疗 (ATM400) 组。我们进行了一系列测试，例如强迫游泳测试 (FST)、蔗糖摄入测试和社会探索。行为测试后，检测血清皮质酮水平，随后对大脑中的 c-Fos、酪氨酸羟化酶 (TH) 和白细胞介素-1 β (IL-1β) 表达进行免疫组织化学测定。ATM 管理与 FST 中的不动时间显着减少有关。此外，与正常组相比，对照组的蔗糖摄入量和社会探索往往减少。然而，ATM 治疗与显着增加的蔗糖摄入量和积极的社会探索有关。在室旁核中，与对照组相比，ATM400组的c-Fos和IL-1β表达显着降低。与对照组相比，高剂量 ATM 给药还与蓝斑中 TH 免疫反应性神经元的表达显着降低有关。