Background: The eosinophil/neutrophil/platelet-to-lymphocyte ratios (ELR, NLR, and PLR) have been used as clinical markers of systemic inflammation. However, they have not yet been tested in various subtypes of immediate hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs). Objectives: To assess the ELR, NLR, and PLR in various types of hypersensitivity to NSAIDs. Materials and Methods: A retrospective analysis of complete blood cell count and the ELR, NLR, and PLR was performed. Appropriate types of hypersensitivity to NSAIDs were diagnosed based on the anamnesis and drug provocation tests. The analysis covered 97 patients. Twenty were diagnosed with NERD (NSAID-exacerbated respiratory disease), 20 with NECD (NSAID-exacerbated cutaneous disease), 38 with NIUA (NSAID-inducted urticaria/angioedema), and 19 with SNIUAA (single-NSAID-induced urticaria/angioedema or anaphylaxis). Two controls groups were included: the first covered 15 patients with bronchial asthma and the second 28 patients with chronic spontaneous urticaria without NSAID hypersensitivity. Results: The NLR did not differ significantly between the NSAID hypersensitivity types. The ELR was significantly higher in NERD patients, and the PLR was significantly lower in NECD patients than in patients with other types of NSAID hypersensitivity and in controls. Conclusions: The ELR and PLR may be useful in differentiating various types of immediate hypersensitivity to NSAIDs. Moreover, the ELR may be helpful in differentiating patients with bronchial asthma with and without NSAID hypersensitivity and PLR in differentiating patients with chronic spontaneous urticaria from NECD.
Int Arch Allergy Immunol

中文翻译：

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嗜酸性粒细胞/嗜中性粒细胞/血小板与淋巴细胞比率对NSAID的各种类型的立即超敏反应：一项初步研究。

背景：嗜酸性粒细胞/嗜中性粒细胞/血小板与淋巴细胞之比（ELR，NLR和PLR）已被用作全身性炎症的临床指标。但是，尚未对非甾体类抗炎药（NSAID）立即过敏的各种亚型进行测试。目的：评估ELR，NLR和PLR对NSAIDs的各种类型的超敏反应。材料和方法：对全血细胞计数和ELR，NLR和PLR进行回顾性分析。根据回忆和药物激发试验，诊断出对NSAID过敏的适当类型。分析覆盖了97名患者。20例被诊断为NERD（NSAID加剧呼吸系统疾病），20例被诊断为NECD（NSAID加剧皮肤病），38例NIUA（NSAID引起的荨麻疹/血管性水肿）和19例SNIUAA（单种NSAID引起的荨麻疹/血管性水肿或）过敏反应）。包括两个对照组：第一组覆盖15例支气管哮喘患者，第二组覆盖28例无NSAID超敏反应的慢性自发性荨麻疹患者。结果：NSAID超敏反应类型之间的NLR没有显着差异。NERD患者的ELR显着较高，NECD患者的PLR显着低于其他类型NSAID超敏反应的患者和对照组。结论： ELR和PLR可能有助于区分各种类型的对NSAID的立即超敏反应。此外，ELR有助于区分患有和不患有NSAID超敏反应和PLR的支气管哮喘患者，以及将NECD慢性自发性荨麻疹患者。
Int Arch过敏免疫