Electrospinning as an effective and accessible method is known to yield scaffolds with desired physical, chemical, and biological properties for tissue engineering. In the present study, captopril (CP)‐loaded polycaprolactone (PCL)/carbon quantum dots (CQDs) nanocomposite scaffolds were fabricated for bone tissue regeneration. The microstructure and hydrophilicity/hydrophobicity ratio of scaffolds were assessed by scanning electron microscopy and wettability test, respectively. The results showed that the presence of CQDs and CP in the scaffolds decreased the fiber diameter (1180 ± 281.5‐345 ± 110 nm) and also it led to an increase in the surface hydrophilicity (137°‐0°) of scaffolds. Evaluation of the scaffolds' functional groups was performed using Attenuated Total Reflectance‐Fourier Transform Infrared spectroscopy. The ultimate tensile strength of scaffolds was in the range of 6.86 ± 0.00 to 22.09 ± 0.06 MPa. Distribution of CQDs in the scaffolds' fibers was investigated by transmission electron microscopy and fluorescent spectrometer. The cell viability, attachment, proliferation, and alkaline phosphatase (ALP) activity of scaffolds were assessed in vitro. Based on the overall results, the scaffold containing CQDs and CP led to a significant increase in the cells' proliferation and ALP activity. Therefore, the PCL/CQDs/CP is recommended as a potential nanocomposite scaffold for bone tissue regeneration.

中文翻译：

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静电纺丝卡托普利负载的PCL-碳量子点纳米复合支架：制备，表征和体外研究

众所周知，静电纺丝是一种有效且易于使用的方法，可产生具有所需的物理，化学和生物学特性的支架，以用于组织工程。在本研究中，制备了负载卡托普利（CP）的聚己内酯（PCL）/碳量子点（CQDs）纳米复合支架，用于骨组织再生。支架的显微结构和亲水/疏水比分别通过扫描电子显微镜和润湿性测试进行评估。结果表明，支架中CQD和CP的存在降低了纤维直径（1180±281.5‐345±110 nm），并导致支架的表面亲水性（137°-0°）增加。使用衰减全反射傅立叶变换红外光谱对支架的官能团进行评估。支架的极限抗拉强度为6.86±0.00至22.09±0.06 MPa。通过透射电子显微镜和荧光光谱仪研究了支架纤维中CQDs的分布。在体外评估支架的细胞活力，附着，增殖和碱性磷酸酶（ALP）活性。根据总体结果，包含CQD和CP的支架导致细胞增殖和ALP活性显着增加。因此，推荐PCL / CQDs / CP作为骨组织再生的潜在纳米复合支架。体外评估支架的碱性磷酸酶（ALP）活性。根据总体结果，包含CQD和CP的支架导致细胞增殖和ALP活性显着增加。因此，推荐PCL / CQDs / CP作为骨组织再生的潜在纳米复合材料支架。体外评估支架的碱性磷酸酶（ALP）活性。根据总体结果，包含CQD和CP的支架导致细胞增殖和ALP活性显着增加。因此，推荐PCL / CQDs / CP作为骨组织再生的潜在纳米复合材料支架。