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Toxoplasma gondii infection impairs the colonic motility of rats due to loss of myenteric neurons.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-08-18 , DOI: 10.1111/nmo.13967
Camila Cristina Alves Machado 1 , Paulo da Silva Watanabe 1 , Joana D'Arc de Lima Mendes 1 , Andréia Carla Eugenio Pupim 1 , Silvia Miyazaki Ortigoza 1 , Heloisa Gonçalves Bergoc 1 , Beatriz de Souza Lima Nino 1 , Marcelo Biondaro Góis 2, 3 , João Luis Garcia 1 , L Ashley Blackshaw 4 , Débora de Mello Gonçales Sant Ana 2 , Eduardo José de Almeida Araújo 1
Affiliation  

Toxoplasma gondii infection causes intestinal inflammation and diarrhea indicating possible intestinal motor dysfunction. Anatomical studies have shown alterations in the colonic myenteric plexus, but it is unknown whether this impacts motility and therefore whether motility is a target for treatment. We determined whether colonic coordinated movements are compromised by toxoplasmic infection and how it is associated with anatomical changes.

中文翻译:

由于肌间神经元的丧失,弓形虫感染会损害大鼠的结肠运动。

弓形虫感染导致肠道炎症和腹泻,表明可能的肠道运动功能障碍。解剖学研究表明结肠肌间神经丛发生了改变,但尚不清楚这是否会影响运动性,因此运动性是否是治疗的目标。我们确定了结肠协调运动是否受到弓形虫感染的影响以及它如何与解剖学变化相关联。
更新日期:2020-08-18
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