Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles.,Macromolecular Bioscience

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Thromboresistance of Polyurethanes Modified with PEO-Silane Amphiphiles.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-18 , DOI: 10.1002/mabi.202000193
Bryan Khai D Ngo ₁ , Kendrick K Lim ₁ , Jessica C Johnson ₁ , Abhishek Jain _{1,

2} , Melissa A Grunlan _{1,

3,

4}

Affiliation

Surface‐induced thrombosis is problematic in blood‐contacting devices composed of silicones or polyurethanes (PUs). Poly(ethylene oxide)‐silane amphiphiles (PEO‐SA) are previously shown effective as surface modifying additives (SMAs) in silicones for enhanced thromboresistance. This study investigates PEO‐SAs as SMAs in a PU at various concentrations: 5, 10, 25, 50, and 100 µmol g⁻¹ PU. PEO‐SA modified PUs are evaluated for their mechanical properties, water‐driven surface restructuring, and adhesion resistance against a human fibrinogen (HF) solution as well as whole human blood. Stability is assessed by monitoring hydrophilicity, water uptake, and mass loss following air‐ or aqueous‐conditioning. PEO‐SA modified PUs do not demonstrate plasticization, as evidenced by minimal changes in glass transition temperature, modulus, tensile strength, and percent strain at break. These also show a concentration‐dependent increase in hydrophilicity that is sustained following air‐ and aqueous‐conditioning for concentrations ≥25 µmol g⁻¹. Additionally, water uptake and mass loss are minimal at all concentrations. Although protein resistance is not enhanced versus an HF solution, PEO‐SA modified PUs have significantly reduced protein adsorption and platelet adhesion from human blood at concentrations ≥10 µmol g⁻¹. Overall, this study demonstrates the versatility of PEO‐SAs as SMAs in PU, which leads to enhanced and sustained hydrophilicity as well as thromboresistance.

中文翻译：

用 PEO-硅烷两亲物改性的聚氨酯的抗血栓性。

在由有机硅或聚氨酯 (PU) 组成的血液接触装置中，表面诱发的血栓形成是有问题的。聚（环氧乙烷）-硅烷两亲物（PEO-SA）先前已被证明可有效用作有机硅中的表面改性添加剂（SMA），以增强抗血栓性。本研究调查了在 PU 中不同浓度的 PEO-SAs 作为 SMAs：5、10、25、50 和 100 µmol g ^-1聚氨酯。对 PEO-SA 改性 PU 的机械性能、水驱动的表面重组以及对人纤维蛋白原 (HF) 溶液和全人血的抗粘附性进行了评估。通过监测空气或水调节后的亲水性、吸水量和质量损失来评估稳定性。PEO-SA 改性的 PU 没有表现出增塑作用，这可以通过玻璃化转变温度、模量、拉伸强度和断裂应变百分比的微小变化来证明。这些还显示出亲水性的浓度依赖性增加，该增加在浓度≥25 µmol g ^{-1 的}空气和水调节后持续. 此外，在所有浓度下，吸水量和质量损失都是最小的。尽管与 HF 溶液相比，蛋白质抗性没有增强，但 PEO-SA 修饰的 PU 在浓度≥10 µmol g ^{-1 时}显着降低了人血液中的蛋白质吸附和血小板粘附。总的来说，这项研究证明了 PEO-SAs 作为 PU 中 SMAs 的多功能性，这导致增强和持续的亲水性以及抗血栓性。

更新日期：2020-08-18

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