Asymmetric Synthesis of Corey Lactone and Latanoprost,European Journal of Organic Chemistry

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Asymmetric Synthesis of Corey Lactone and Latanoprost
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-08-19 , DOI: 10.1002/ejoc.202001063
Nariyoshi Umekubo ₁ , Yujiro Hayashi ₁

Affiliation

Corey lactone and latanoprost were synthesized in nearly enantiomeric pure forms following the concepts of pot and time economy using diphenylprolinol silyl ether mediated formal [3+2] cycloaddition reaction as key step. Corey lactone was synthesized in a one‐pot reaction within 152‐minutes in a total yield of 50 %, while latanoprost was synthesized through a seven‐pot synthesis with five purifications in a total yield of 25 %.

中文翻译：

科里内酯和拉坦前列素的不对称合成

按照二元脯氨醇甲硅烷基醚介导的正式[3 + 2]环加成反应为关键步骤，按照节省时间和时间的概念，以几乎对映体的纯形式合成了Corey内酯和latanoprost。Corey内酯是在152分钟内通过单锅反应合成的，总收率为50％，而拉坦前列素是通过7锅合成法经五次纯化合成的，总收率为25％。

更新日期：2020-10-17

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