Genome‐wide association studies are rapidly advancing our understanding of the genetic architecture of complex disorders, including many psychiatric conditions such as major depression, schizophrenia, and substance use disorders. One common goal of genome‐wide association studies is to use findings for enhanced clinical prediction in the future, which can aid in identifying at‐risk individuals to enable more effective prevention screening and treatment strategies. In order to achieve this goal, we first need to gain a better understanding of the issues surrounding the return of complex genetic results. In this article, we summarize the current literature on: (a) genetic literacy in the general population, (b) the public's interest in receiving genetic test results for psychiatric conditions, (c) how individuals react to and interpret their genotypic information for specific psychiatric conditions, and (d) gaps in our knowledge that will be critical to address as we move toward returning genotypic information for psychiatric conditions in both research and clinical settings. By reviewing extant studies, we aim to increase awareness of the potential benefits and consequences of returning genotypic information for psychiatric conditions.

中文翻译：

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精神疾病的遗传反馈：我们现在在哪里，我们要去哪里。

全基因组关联研究正在迅速增进我们对复杂疾病遗传结构的理解，包括许多精神疾病，例如严重抑郁症，精神分裂症和药物滥用疾病。全基因组关联研究的一个共同目标是在将来利用发现结果来增强临床预测，这可以帮助识别有风险的个体，从而实现更有效的预防筛查和治疗策略。为了实现这一目标，我们首先需要更好地了解围绕复杂遗传结果返回的问题。在本文中，我们总结了有关以下方面的最新文献：（a）普通人群的基因素养，（b）公众对于接受针对精神疾病的基因检测结果的兴趣，（c）个人如何针对特定的精神病学状况做出反应并解释其基因型信息，以及（d）我们在研究和临床环境中都将返回针对精神病学状况的基因型信息时所面临的关键知识缺口。通过审查现有研究，我们旨在提高人们对针对精神疾病返回基因型信息的潜在益处和后果的认识。