Autophagy is a highly conserved degradation pathway that ensures nutrient recycling and removal of unwanted substrates. This process has a fundamental role in stress adaptation and maintenance of cellular homeostasis. Here, we discuss emerging aspects of the autophagy–RNA interplay, including autophagy-mediated degradation of RNA, RNA-binding proteins (RBPs), and ribonucleoprotein (RNP) complexes. Beyond degradation, we review new roles for autophagy players in the secretion and intracellular transport of RNA and related complexes. We discuss the physiological importance of these events for RNA homeostasis and gene expression programs, as well as their implications for disease, including cancer and neurodegeneration. Lastly, we examine how post-transcriptional regulation of autophagy, through specialized processing and selective translation of key transcripts, challenges and updates our current view of autophagy complexity.

自噬是一种高度保守的降解途径，可确保营养物质循环利用并去除不需要的底物。该过程在压力适应和维持细胞稳态中具有基本作用。在这里，我们讨论了自噬与RNA相互作用的新兴方面，包括自噬介导的RNA降解，RNA结合蛋白（RBP）和核糖核蛋白（RNP）复合物。除降解外，我们还回顾了自噬玩家在RNA和相关复合物的分泌和细胞内运输中的新作用。我们讨论了这些事件对RNA稳态和基因表达程序的生理重要性，以及它们对疾病的影响，包括癌症和神经变性。最后，我们研究了自噬的转录后调控，