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Efficient synthesis of perfluoroalkylated quinolines via a metal-free cascade Michael addition/intramolecular rearrangement cyclization process
Tetrahedron ( IF 2.1 ) Pub Date : 2020-08-19 , DOI: 10.1016/j.tet.2020.131518 Jun Wu , Hui Zhang , Xiao Ding , Xuefei Tan , Hong C. Shen , Jie Chen , Liping Song , Weiguo Cao
中文翻译:
通过无金属级联迈克尔加成/分子内重排环化过程高效合成全氟烷基化喹啉
更新日期:2020-10-06
Tetrahedron ( IF 2.1 ) Pub Date : 2020-08-19 , DOI: 10.1016/j.tet.2020.131518 Jun Wu , Hui Zhang , Xiao Ding , Xuefei Tan , Hong C. Shen , Jie Chen , Liping Song , Weiguo Cao
2-Perfluoroalkylated quinolines were efficiently synthesized via the Michael addition of perfluoroalk-2-ynoates with isatins, followed by the reaction with alcohols through an intramolecular rearrangement cyclization in the presence of Na2CO3. Under the mild and metal-free reaction conditions, a broad scope of quinolines was synthesized and the mechanism was proposed.
中文翻译:
通过无金属级联迈克尔加成/分子内重排环化过程高效合成全氟烷基化喹啉
通过全氟烷基-2-壬酸酯的迈克尔加成与靛红,然后在Na 2 CO 3存在下通过分子内重排环化与醇反应,可以有效地合成2-全氟烷基化的喹啉。在温和无金属的反应条件下,合成了范围广泛的喹啉并提出了机理。