Quaternary ammonium salts derived from amino acids with large steric hindrance group have been designed and synthesized, which promoted the asymmetric Mannich reaction of glycine imines with N-Boc-aldimines in excellent yields with high enantio- and diastereo-control compared with known catalysts of this type reported by our group.

中文翻译：

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具有大位阻基团的α-氨基酸衍生的新型季铵盐及其在不对称曼尼希反应中的应用

设计并合成了具有大空间位阻基团的氨基酸衍生的季铵盐，与已知的催化剂相比，它促进了甘氨酸亚胺与N -Boc-醛亚胺的不对称曼尼希反应，收率高，对映体和非对映体控制率高我们小组报告的类型。