Hippo signaling is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis, and stem cell self-renewal by “turning off” or “turning on” the kinase cascade chain reaction to manipulate the expression of downstream genes. Dysregulation of the Hippo pathway contributes to cancer development and metastasis. Emerging evidence has revealed new insights into tumorigenesis through the interplay between the Hippo pathway and non-coding RNAs (ncRNAs), especially microRNA, long non-coding RNA and circular RNA. Here, we reviewed the interactions between the Hippo pathway and ncRNAs and their implication for a variety of tumor-promoting or tumor-repressing effects. These interactions have the potential to serve as cancer biomarkers and therapeutic targets in clinical applications.

河马信号是一种进化保守的途径，通过“关闭”或“开启”激酶级联反应来控制下游基因的表达，从而调节细胞增殖，凋亡和干细胞自我更新，从而控制器官的大小。河马途径的失调有助于癌症的发展和转移。新兴证据通过Hippo途径与非编码RNA（ncRNA），特别是microRNA，长非编码RNA和环状RNA之间的相互作用揭示了对肿瘤发生的新见解。在这里，我们审查了河马途径和ncRNAs之间的相互作用，以及它们对多种促肿瘤或抑制肿瘤作用的意义。这些相互作用有潜力在临床应用中充当癌症生物标志物和治疗靶标。