The influence of the dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) bis(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide (GSB-106, dosage form) during three-day peroral administration at a dose of 0.1 mg/kg on the 1% sucrose solution preference test and the content of postsynaptic density protein (PSD-95) in the prefrontal cortex and hippocampus of C57Bl/6 mice was studied in an acute three-day social defeat stress model. The preference for sucrose solution decreased and the PSD-95 content in the prefrontal cortex was halved statistically significantly in stressed mice as compared to control animals. The hippocampal PSD-95 content in stressed animals did not change. Anhedonia was completely prevented after each stress session according to the sucrose preference test with peroral administration of GSB-106 at a dose of 0.1 mg/kg once per day for three days. GSB-106 did not reduce the prefrontal PSD-95 content of stressed animals during the experiment.

中文翻译：

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GSB-106 脑源性神经营养因子的二肽模拟物在小鼠急性社会失败压力条件下防止快感缺乏发展

脑源性神经营养因子（BDNF）双（N-单琥珀酰-L-丝氨酰-L-赖氨酸）六亚甲基二酰胺（GSB-106，剂型）的二聚二肽模拟物在以0.1的剂量口服给药三天期间的影响在为期三天的急性社交失败应激模型中，研究了 C57Bl/6 小鼠前额叶皮层和海马中 1% 蔗糖溶液偏好测试中的 mg/kg 和突触后密度蛋白 (PSD-95) 的含量。与对照动物相比，应激小鼠对蔗糖溶液的偏好降低，前额叶皮层中的 PSD-95 含量在统计学上显着减半。应激动物的海马 PSD-95 含量没有变化。根据蔗糖偏好试验，口服剂量为 0 的 GSB-106 在每次应激后完全防止快感缺失。1 mg/kg 每天一次，连续三天。在实验过程中，GSB-106 没有减少应激动物的前额叶 PSD-95 含量。