The generative function of female rats upon intragastric administration of tablets of gestobutanoil at doses of 0.25 and 2.5 mg/kg (calculated doses corresponding to the therapeutic dose and ten times higher) was studied. Gestobutanoil was administered two weeks before pregnancy, which corresponded to 2 – 3 estrous cycles. Gestobutanoil at a dose of 0.25 mg/kg exhibited progestogen activity. The duration of estrus, the fertility index, and the numbers of pregnancy corpus lutea and live fetuses increased in female rats. Administration of gestobutanoil at a dose of 2.5 mg/kg produced a contraceptive effect that manifested as a prolonged estrous cycle and a reduction of fertility and numbers of corpus lutea and fetuses. Gestobutanoil at both doses did not produce a teratogenic effect and did not affect the vitality of F1 offspring (survival, body-weight dynamics, sensory-motor behavior development).

中文翻译：

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雌性大鼠灌胃新类固醇药物 Gestobutanoil 后的生殖功能

研究了雌性大鼠在胃内给药剂量为 0.25 和 2.5 mg/kg（计算剂量对应于治疗剂量和十倍以上）的孕酮丁油片后的生殖功能。Gestobutanoil 在怀孕前两周服用，相当于 2-3 个发情周期。剂量为 0.25 mg/kg 的 Gestobutanoil 表现出孕激素活性。雌性大鼠发情持续时间、生育指数、妊娠黄体和活胎数均增加。以 2.5 mg/kg 的剂量服用 gestobutanoil 会产生避孕效果，表现为发情周期延长、生育能力和黄体和胎儿数量减少。两种剂量的 Gestobutanoil 均未产生致畸作用，也不影响 F1 后代的活力（存活、