In this paper, three-dimensional images were used to analyze the association between dose-volume parameters and radiation-induced brain edema in patients with a brain tumor after receiving stereotactic radiosurgery (SRS). The computed tomography (CT), magnetic resonance images (MRI) and treatment parameters were transferred through the treatment planning system (Multiplan, version 5.1.3). The correlation between the dose of radiation therapy and brain edema was evaluated by image processing methods, such as image normalization, registration, filtering, segmentation, and feature extraction. The association was evaluated by volume index and intersection index. The study results suggest that the volume receiving radiation dose above 30% of the prescribed dose is highly associated with the brain edema in brain tumor patients after SRS. The small number of patients limits the study. Further investigation with larger populations and long-term epidemiological studies are required.

中文翻译：

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分析接受立体定向放射外科治疗的脑肿瘤患者的剂量体积参数与辐射诱发的脑水肿之间的关系

本文利用三维图像分析了脑肿瘤患者接受立体定向放射外科手术 (SRS) 后剂量体积参数与辐射诱发的脑水肿之间的关联。计算机断层扫描 (CT)、磁共振图像 (MRI) 和治疗参数通过治疗计划系统（Multiplan，版本 5.1.3）传输。采用图像归一化、配准、滤波、分割、特征提取等图像处理方法评价放疗剂量与脑水肿的相关性。该关联通过体积指数和交叉指数进行评估。研究结果表明，接受辐射剂量超过规定剂量 30% 的体积与 SRS 后脑肿瘤患者的脑水肿高度相关。少数患者限制了研究。需要对更大的人群进行进一步的调查和长期的流行病学研究。