Inclusion of a large amount of deep eutectic solvent (DES) in a microemulsion (ME) may enhance transdermal permeation of resveratrol (RSV) due to its high solubility in DES of the inner phase. We prepared MEs with different DES loading and surfactant composition, and investigated the entrapment amount of RSV, the structures of the MEs, and their skin penetration amount. We found that MEs at Tween-80/Span-20 = 4/1 (wt/wt) (T4S1) were able to contain the largest amount of DES in the inner phase. The structural characterization results showed that T4S1-MEs containing more than 20 wt% DES and less than 10 wt% DES formed a vesicle containing DES in the membrane of surfactants and a spherical micelle containing DES in the inner phase, respectively. The vesicles containing more than 20 wt% DES were able to trap a larger amount of RSV and deliver more RSV through the stratum corneum compared to the spherical micelles containing less than 10 wt% DES.

中文翻译：

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评估含有大量深共晶溶剂作为白藜芦醇潜在透皮载体的微乳

由于其在内相DES中的高溶解度，在微乳液（ME）中包含大量的深共晶溶剂（DES）可能会增强白藜芦醇（RSV）的透皮渗透性。我们制备了具有不同DES含量和表面活性剂组成的ME，并研究了RSV的包封量，ME的结构及其皮肤渗透量。我们发现在Tween-80 / Span-20 = 4/1（wt / wt）（T4S1）下的ME能够在内相中包含最大量的DES。结构表征结果表明，包含大于20wt％的DES和小于10wt％的DES的T4S1-MEs分别在表面活性剂的膜中形成包含DES的囊泡和在内相中包含DES的球形胶束。