The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer’s law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods. All the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA). Three different spectrophotometric methods were developed for satranidazole (STZ) using various inorganic and organic solvents. The analytical methods are found to be simple, sensitive, rapid, specific, and economic, and it can be conveniently employed for the routine analysis, quality control. The sample recoveries from the formulation were in good agreement with its respective label claim.

中文翻译：

---

改进的综合分析方法用于评估药物和产品中的替硝苯达唑

本研究的目的是通过简单，经济，灵敏和可重复的分光光度法改进用于评估药物和产品中的赛丹尼唑的综合分析方法。通过使用各种溶剂以三种不同方法对药物进行了分析，其中satranidazole（STZ）在一阶导数光谱中显示出不同的最大吸收值和尖峰。使用所有三种方法确定每种溶剂的比尔定律范围，相关系数，表观摩尔吸收率等。发现所有分析结果均令人满意，该结果已针对各种参数进行了统计学验证，并根据国际协调会议（ICH）指南进行了回收研究。还使用一种方差分析（ANOVA）对开发的方法进行了统计比较。开发了三种不同的分光光度法，分别使用多种无机和有机溶剂制备了替硝唑（STZ）。分析方法被发现简单，灵敏，快速，专一且经济，可方便地用于常规分析和质量控制。从制剂中回收的样品与其相应的标签要求非常一致。