Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.,Stem Cell Research & Therapy

当前位置： X-MOL 学术 › Stem Cell Res. Ther. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells.
Stem Cell Research & Therapy ( IF 7.1 ) Pub Date : 2020-08-18 , DOI: 10.1186/s13287-020-01875-5
Lei Shu _{1,

2} , Changming Niu ₃ , Ruyou Li ₄ , Tingrong Huang ₅ , Yan Wang ₆ , Mao Huang ₇ , Ningfei Ji ₇ , You Zheng ₅ , Xiaolin Chen ₁ , Lei Shi ₁ , Mingjing Wu ₁ , Kaili Deng ₁ , Jing Wei ₁ , Xueli Wang ₁ , Yang Cao ₁ , Jiaxin Yan ₁ , Ganzhu Feng ₈

Affiliation

COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19. To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19. Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. The incidence of progression from severe to critical illness, 28-day mortality, clinical symptom improvement, time to clinical symptom improvement, hematologic indicators including C-reactive protein, lymphocyte number, and interleukin 6, and imaging changes were observed and compared between the two groups. The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. Clinical symptoms of weakness and fatigue, shortness of breath, and low oxygen saturation obviously improved beginning on the third day of stem cell infusion and reached a significant difference on day 7. CRP and IL-6 levels were significantly lower from day 3 of infusion, the time for the lymphocyte count to return to the normal range was significantly faster, and lung inflammation absorption was significantly shorter on CT imaging in the hUC-MSC group than in the control group. Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19. Chinese Clinical Trial Registration; ChiCTR2000031494; Registered on 2 April 2020; http:// www.medresman.org

更新日期：2020-08-18

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11