Smart design for a flexible, functionalized and electroresponsive hybrid platform based on poly(3,4-ethylenedioxythiophene) derivatives to improve cell viability,Journal of Materials Chemistry B

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Smart design for a flexible, functionalized and electroresponsive hybrid platform based on poly(3,4-ethylenedioxythiophene) derivatives to improve cell viability
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-08-17 , DOI: 10.1039/d0tb01259a
Brenda G. Molina _{1,

2,

3,

4,

5} , Anca D. Bendrea _{6,

7,

8} , Sonia Lanzalaco _{1,

2,

3,

4,

5} , Lourdes Franco _{1,

2,

3,

4,

5} , Luminita Cianga _{6,

7,

8} , Luis J. del Valle _{1,

2,

3,

4,

5} , Jordi Puiggali _{1,

2,

3,

4,

5} , Pau Turon _{5,

9,

10} , Elaine Armelin _{1,

2,

3,

4,

5} , Ioan Cianga _{6,

7,

8} , Carlos Aleman _{1,

2,

3,

4,

5}

Affiliation

Development of smart functionalized materials for tissue engineering has attracted significant attention in recent years. In this work we have functionalized a free-standing film of isotactic polypropylene (i-PP), a synthetic polymer that is typically used for biomedical applications (e.g. fabrication of implants), for engineering a 3D all-polymer flexible interface that enhances cell proliferation by a factor of ca. three. A hierarchical construction process consisting of three steps was engineered as follows: (1) functionalization of i-PP by applying a plasma treatment, resulting in i-PP_f; (2) i-PP_f surface coating with a layer of polyhydroxymethy-3,4-ethylenedioxythiophene nanoparticles (PHMeEDOT NPs) by in situ chemical oxidative polymerization of HMeEDOT; and (3) deposition on the previously activated and PHMeEDOT NPs coated i-PP film (i-PP_f/NP) of a graft conjugated copolymer, having a poly(3,4-ethylenedioxythiophene) (PEDOT) backbone, and randomly distributed short poly(ε-caprolactone) (PCL) side chains (PEDOT-g-PCL), as a coating layer of ∼9 μm in thickness. The properties of the resulting bioplatform, which can be defined as a robust macroscopic composite coated with a “molecular composite”, were investigated in detail, and both adhesion and proliferation of two human cell lines have been evaluated, as well. The results demonstrate that the incorporation of the PEDOT-g-PCL layer significantly improves cell attachment and cell growth not only when compared to i-PP but also with respect to the same platform coated with only PEDOT, constructed in a similar manner, as a control.

中文翻译：

基于聚（3,4-乙撑二氧噻吩）衍生物的灵活，功能化和电响应混合平台的智能设计，可提高细胞活力

近年来，用于组织工程的智能功能材料的开发引起了广泛的关注。在这项工作中，我们对全同立构聚丙烯（i-PP）的独立膜进行了功能化，这是一种通常用于生物医学应用（例如植入物的制造）的合成聚合物，用于设计3D全聚合物柔性界面以增强细胞增殖的因数约三。设计了由三个步骤组成的分层构建过程，如下所示：（1）通过应用等离子体处理对i-PP进行功能化，生成i-PP _f；（2）i-PP _f表面涂覆原位聚羟基甲基3,4-乙撑二氧噻吩纳米颗粒（PHMeEDOT NPs）HMeEDOT的化学氧化聚合；（3）沉积在具有聚（3,4-乙撑二氧噻吩）（PEDOT）主链且随机分布的短接枝的接枝共轭共聚物的预先活化且经PHMeEDOT NPs涂覆的i-PP膜（i-PP _f / NP）聚（ε-己内酯）（PCL）侧链（PEDOT- g -PCL），涂层的厚度约为9μm。详细研究了所得生物平台的特性，该平台可以定义为包覆有“分子复合物”的坚固的宏观复合物，并且还评估了两种人类细胞系的粘附和增殖。结果表明，PEDOT- g的掺入-PCL层不仅与i-PP相比，而且相对于仅涂有PEDOT的相同平台（与对照物相比）均显着改善了细胞附着和细胞生长。

更新日期：2020-10-07

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