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An efficient [3+2] annulation for the asymmetric synthesis of densely-functionalized pyrrolidinones and γ-butenolides.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-18 , DOI: 10.1039/d0cc05188h
Hui Qian 1 , Song Sun 2 , Wanxiang Zhao 3 , Jianwei Sun 1
Affiliation  

Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging. This process also represents a rare asymmetric synthesis of enantrioenriched molecules from siloxy alkynes.

中文翻译:

高效[3 + 2]环空用于稠密官能化的吡咯烷酮和γ-丁烯醇内酯的不对称合成。

本文公开了一种新的[3 + 2]硅烷氧基炔烃环化反应,可提供对苯二酚和γ-丁烯化物的高度对映体富集,致密取代的吡咯烷酮和它们的直接合成方法,这些化合物的直接合成仍具有挑战性。该过程还代表了从甲硅烷氧基炔烃中稀有的对映体富集分子的罕见不对称合成。
更新日期:2020-09-24
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