RNA-seq technology is widely used in various transcriptomic studies and provides great opportunities to reveal the complex structures of transcriptomes. To effectively analyze RNA-seq data, we introduce a novel transcriptome assembler, TransBorrow, which borrows the assemblies from different assemblers to search for reliable subsequences by building a colored graph from those borrowed assemblies. Then, by seeding reliable subsequences, a newly designed path extension strategy accurately searches for a transcript-representing path cover over each splicing graph. TransBorrow was tested on both simulated and real data sets and showed great superiority over all the compared leading assemblers.

中文翻译：

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TransBorrow：通过从不同的组装者那里借用组装来进行基因组引导的转录组组装。

RNA-seq技术广泛应用于各种转录组学研究，为揭示转录组的复杂结构提供了很好的机会。为了有效地分析 RNA-seq 数据，我们引入了一种新的转录组组装程序 TransBorrow，它借用来自不同组装程序的程序集，通过从这些借用的程序集构建彩色图来搜索可靠的子序列。然后，通过播种可靠的子序列，新设计的路径扩展策略在每个拼接图上准确地搜索表示转录本的路径覆盖。TransBorrow 在模拟和真实数据集上进行了测试，并显示出优于所有比较领先的组装商的巨大优势。