Airmen and health-care providers' attitudes toward the use of genomic sequencing in the US Air Force: findings from the MilSeq Project.,Genetics in Medicine

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Airmen and health-care providers' attitudes toward the use of genomic sequencing in the US Air Force: findings from the MilSeq Project.
Genetics in Medicine ( IF 6.6 ) Pub Date : 2020-08-18 , DOI: 10.1038/s41436-020-0928-9
Stacey Pereira ₁ , Rebecca L Hsu ₁ , Rubaiya Islam ₁ , Jill Oliver Robinson ₁ , Rishab Ramapriyan ₂ , Emily Sirotich _{3,

4} , Megan D Maxwell _{5,

6} , Mary Majumder ₁ , Carrie L Blout ₄ , Kurt D Christensen ₇ , Maxwell Mehlman ₈ , Efthimios Parasidis ₉ , Cubby L Gardner ₁₀ , Jacqueline M Killian ₁₁ , Mauricio De Castro ₁₂ , Robert C Green _{4,

13,

14} , , Amy L McGuire ₁

Affiliation

Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, USA.
Rice University, Houston, TX, USA.
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Brigham and Women's Hospital, Boston, MA, USA.
University Health System, San Antonio, TX, USA.
University of Texas Health Science Center, San Antonio, TX, USA.
Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Law-Medicine Center at Case Western University's School of Medicine, Cleveland, OH, USA.
Moritz College of Law and the College of Public Health, The Ohio State University, Columbus, OH, USA.
Defense Health Headquarters, Falls Church, VA, USA.
Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Air Force Medical Genetics Center, Keesler AFB, Biloxi, MS, USA.
G2P Research Program, Harvard Medical School, Boston, MA, USA.
Broad Institute, Cambridge, MA, USA.

Purpose

The use of genomic sequencing (GS) in military settings poses unique considerations, including the potential for GS to impact service members’ careers. The MilSeq Project investigated the use of GS in clinical care of active duty Airmen in the United States Air Force (USAF).

Methods

We assessed perceived risks, benefits, and attitudes toward use of GS in the USAF among patient participants (n = 93) and health-care provider participants (HCPs) (n = 12) prior to receiving or disclosing GS results.

Results

Participants agreed that there are health benefits associated with GS (90% patients, 75% HCPs), though more HCPs (75%) than patients (40%) agreed that there are risks (p = 0.048). The majority of both groups (67% HCPs, 77% patients) agreed that they trust the USAF with genetic information, but far fewer agreed that genetic information should be used to make decisions about deployment (5% patients, 17% HCPs) or duty assignments (3% patients, 17% HCPs). Despite their hesitancy, patients were supportive of the USAF testing for nondisease traits that could impact their duty performance. Eighty-seven percent of patients did not think their GS results would influence their career.

Conclusion

Results suggest favorable attitudes toward the use of GS in the USAF when not used for deployment or assignment decisions.

中文翻译：

飞行员和医疗保健提供者对美国空军使用基因组测序的态度：MilSeq 项目的调查结果。

目的

在军事环境中使用基因组测序 (GS) 提出了独特的考虑因素，包括 GS 影响军人职业生涯的潜力。MilSeq 项目调查了 GS 在美国空军 (USAF) 现役飞行员临床护理中的使用情况。

方法

在收到或披露 GS 结果之前，我们评估了患者参与者 ( n = 93) 和医疗保健提供者参与者 (HCP) ( n = 12)对在美国空军使用 GS 的感知风险、益处和态度。

结果

参与者同意 GS 具有健康益处（90% 的患者，75% 的 HCP），但同意存在风险的 HCP（75%）多于患者（40%）（p = 0.048）。两组中的大多数（67% HCP，77% 患者）都同意他们信任美国空军的遗传信息，但很少有人同意应使用遗传信息来做出有关部署（5% 患者，17% HCP）或执勤的决定分配（3% 患者，17% HCP）。尽管犹豫不决，患者还是支持美国空军对可能影响其执行任务的非疾病特征进行检测。87% 的患者认为他们的 GS 结果不会影响他们的职业生涯。