We determined that a genetic haplotype increased the risk of hyperuricaemia and it interacted with lifestyle factors, including nutrients in 28,445 middle-aged Koreans. ABCG2_rs2231142, PKD2_rs2725220 and SLC2A9_rs3733591 were selected from GWAS based on hyperuricaemia (≥7 mg/dL; p = 6.88E-42, 1.56E-26 and 1.01E-20, respectively). Hyperuricaemia and gout were elevated by 3.93- and 3.23-fold, respectively, by the minor alleles as compared with the major alleles of the haplotype of the selected 3 SNPs after adjusting for covariates. The haplotype significantly interacted with alcohol, chicken and processed meat intakes, and smoking status in the hyperuricaemia risk (p = 0.002–0.007). Minor alleles of the haplotype had an association with hyperuricaemia as compared with major alleles particularly in high intakes of alcohol (2g/day), chicken (6.3g/day), and processed meat (3g/day) and smokers. In conclusion, people carrying minor alleles of the haplotype of SLC2A9_rs3733591, PKD2_rs2725220 and ABCG2_rs2231142 should avoid diets high in chicken and processed meat, alcohol drinking, and cigarette smoking to protect against hyperuricaemia risk.

我们确定遗传单倍型会增加高尿酸血症的风险，并且与生活方式因素（包括28,445名中年韩国人的营养素）相互作用。ABCG2 _rs2231142，PKD2 _rs2725220和SLC2A9 _rs3733591从GWAS选择基于高尿酸血症（≥7毫克/分升; p  = 6.88E-42，1.56E-26和1.01E-20，分别地）。校正协变量后，与选定的3个SNP单倍型的主要等位基因相比，次要等位基因使高尿酸血症和痛风分别升高了3.93和3.23倍。在高尿酸血症风险中，单倍型与酒精，鸡肉和加工肉的摄入量以及吸烟状况显着相互作用（p = 0.002-0.007）。与主要等位基因相比，单倍型次要等位基因与高尿酸血症有关，尤其是在高摄入酒精（2g /天），鸡肉（6.3g /天），加工肉（3g /天）和吸烟者中。总之，携带SLC2A9 _rs3733591，PKD2 _rs2725220和ABCG2 _rs2231142单倍型的次要等位基因的人应避免在鸡肉和加工肉中饮食较多，饮酒和吸烟，以预防高尿酸血症的风险。