^§ These authors contributed equally to the work

Abstract

A catalytic asymmetric substitution of 3-substituted 2-indolylmethanols with 2-naphthols has been established under the catalysis of chiral phosphoric acid. By this approach, a series of structurally diversified triarylmethane derivatives were obtained in moderate to high yields with good enantioselectivities (up to 97% yield, 95:5 er). This approach not only enriches the chemistry of 2-indolylmethanol-inolved catalytic asymmetric substitutions, but also provides a useful method for the enantioselective synthesis of chiral triarylmethane derivatives.

中文翻译：

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3-取代的2-吲哚基甲醇与2-萘酚的催化不对称取代反应

^§这些作者对工作做出了同等贡献

抽象

在手性磷酸的催化下，已经建立了2-萘酚对3-取代的2-吲哚基甲醇的催化不对称取代。通过这种方法，以中等至高产率获得了具有良好对映选择性的一系列结构多样化的三芳基甲烷衍生物（高达97％，95：5 er）。这种方法不仅丰富了2-吲哚基甲醇无溶剂催化的不对称取代的化学反应，而且为手性三芳基甲烷衍生物的对映选择性合成提供了一种有用的方法。