Supramolecular Gelatin Networks Based on Inclusion Complexes.,Macromolecular Bioscience

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Supramolecular Gelatin Networks Based on Inclusion Complexes.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-08-17 , DOI: 10.1002/mabi.202000221
Candy Löwenberg ₁ , Giuseppe Tripodo ₁ , Konstanze K Julich-Gruner ₁ , Axel T Neffe ₁ , Andreas Lendlein _{1,

2}

Affiliation

Hydrogel forming physical networks based on gelatin are an attractive approach toward multifunctional biomaterials with the option of reshaping, self‐healing, and stimuli‐sensitivity. However, it is challenging to design such gelatin‐based hydrogels to be stable at body temperature. Here, gelatin functionalized with desaminotyrosine (DAT) or desaminotyrosyl tyrosine (DATT) side chains is crosslinked with cyclodextrin (CD) dimers under formation of inclusions complexes. The supramolecular networks displayed at room temperature decreased water uptake (200–600 wt% for DAT‐based systems, 200 wt% for DATT based systems), and increased storage moduli up to 25.6 kPa determined by rheology compared to DAT(T) gelatin. The gel–sol transition temperature increased from 33 up to 42 °C. The presented system that is completely based on natural building blocks may form the basis for materials that may potentially respond by dissolution or changes of properties to changes in environmental conditions or to the presence of CD guest molecules.

中文翻译：

基于包合物的超分子明胶网络。

基于明胶的水凝胶形成物理网络是多功能生物材料的一种有吸引力的方法，具有重塑、自愈和刺激敏感性的选项。然而，设计这种在体温下稳定的基于明胶的水凝胶具有挑战性。在这里，用脱氨基酪氨酸 (DAT) 或脱氨基酪氨酸酪氨酸 (DATT) 侧链功能化的明胶在形成包合物复合物的情况下与环糊精 (CD) 二聚体交联。与 DAT(T) 明胶相比，室温下显示的超分子网络降低了吸水量（基于 DAT 的系统为 200-600 wt%，基于 DATT 的系统为 200 wt%），并增加了由流变学确定的高达 25.6 kPa 的储存模量。凝胶-溶胶转变温度从 33 °C 增加到 42 °C。

更新日期：2020-10-12

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