Effect of dietary inclusion of pumpkin (Cucurbita pepo L) seed on nephrotoxicity occasioned by cisplatin in experimental rats.,Journal of Food Biochemistry

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Effect of dietary inclusion of pumpkin (Cucurbita pepo L) seed on nephrotoxicity occasioned by cisplatin in experimental rats.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-18 , DOI: 10.1111/jfbc.13439
Folake L Oyetayo ₁ , Seun F Akomolafe ₁ , Tope J Osesanmi ₁

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The study evaluated the effect of dietary inclusion of pumpkin (Cucurbita pepo L) seed (raw and roasted) on nephrotoxicity caused by cisplatin in rats. Rats were divided into control group, cisplatin‐induced nephrotoxic untreated group, nephrotoxic‐treated groups with Methimazole, dietary regimen containing raw pumpkin seed (5% and 10%) and roasted pumpkin seed (5% and 10%) for 14 days. Results acquired uncovered that cisplatin intoxication significantly increased (p ≤ .05) the levels of renal biomarkers, arginase activity, 8‐hydroxy‐2¹‐deoxy guanosine (8‐OHdG), malondialdehyde (MDA), and reactive oxygen species (ROS) levels as well as significant decrease in functional sulfhydryl groups, nitric oxide levels, and antioxidant enzyme activities in rats' kidney when compared to the control group. These adverse changes, due to cisplatin inebriation in rodents, were in any case, forestalled by pre‐treatment with pumpkin seed inclusive diet. This holds promise for the use of pumpkin seed as a food supplement in the management of nephrotoxic‐related disorders.

中文翻译：

饮食中添加南瓜（Cucurbita pepo L）种子对实验大鼠顺铂引起的肾毒性的影响。

该研究评估了膳食中添加南瓜籽（生的和烤的）对顺铂引起的大鼠肾毒性的影响。大鼠分为对照组、顺铂肾毒性未治疗组、甲硫咪唑肾毒性治疗组，饮食方案为生南瓜子（5%和10%）和烤南瓜子（5%和10%），连续14天。获得的结果显示，顺铂中毒显着增加 ( p ≤ .05) 肾脏生物标志物、精氨酸酶活性、8-羟基-2 ^{1 -}脱氧鸟苷 (8-OHdG)、丙二醛 (MDA) 和活性氧 (ROS) 的水平与对照组相比，大鼠肾脏中功能性巯基、一氧化氮水平和抗氧化酶活性显着降低。在任何情况下，这些由于啮齿类动物顺铂中毒而引起的不良变化都可以通过含南瓜籽饮食的预处理来预防。这为使用南瓜子作为食品补充剂来治疗肾毒性相关疾病带来了希望。

更新日期：2020-10-11

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