Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats.,Journal of Food Biochemistry

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Zanthoxylum alkylamides improve amino acid metabolism in type 2 diabetes mellitus rats.
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-08-18 , DOI: 10.1111/jfbc.13441
Xunyu Wei _{1,

2,

3} , Bing Yang _{1,

2,

3} , Guangjing Chen ₄ , Di Wang _{1,

2,

3} , Yue Shi _{1,

2,

3} , Qiaoli Chen _{1,

2,

3} , Jianquan Kan _{1,

2,

3}

Affiliation

To investigate the effect of Zanthoxylum alkylamides (ZA) on amino acid metabolism of type 2 diabetes mellitus (T2DM), the present study was performed with T2DM rats model induced with high fat and sugar fodder combined with low‐dose of streptozotocin. ZA were fed to rats at three different doses of 2, 4, and 8 mg/kg for 28 days and metformin was fed to rats at 135 mg/kg as positive control. The results showed that compared with the normal control, the amino acid levels and the expression of related carrier genes were disordered in T2DM rats. Compared with the model, different doses of ZA could significantly resist (p < .05) the decrease in body weight of T2DM rats and improve hyperglycemia, with the best result observed with the high dose (8 mg/kg). Different doses of ZA could ameliorate the levels of 19 kinds of amino acid in the plasma, jejunum, liver, and skeletal muscle of T2DM rats by regulating the expression of related amino acid transporters including LAT1, SNAT2, CAT1, et al. to thereby ameliorating amino acid metabolism disorder in T2DM rats.

中文翻译：

花椒烷基酰胺可改善 2 型糖尿病大鼠的氨基酸代谢。

为探讨花椒烷基酰胺（ZA）对2型糖尿病（T2DM）氨基酸代谢的影响，本研究采用高脂高糖饲料联合低剂量链脲佐菌素诱导的T2DM大鼠模型。 ZA以2、4和8 mg/kg三种不同剂量喂给大鼠28天，二甲双胍以135 mg/kg喂给大鼠作为阳性对照。结果显示，与正常对照相比，T2DM大鼠氨基酸水平及相关载体基因表达发生紊乱。与模型相比，不同剂量的ZA均能显着抵抗( p <.05)T2DM大鼠体重下降，改善高血糖，其中高剂量(8mg/kg)效果最好。不同剂量的ZA可通过调节LAT1、SNAT2、CAT1等相关氨基酸转运蛋白的表达来改善T2DM大鼠血浆、空肠、肝脏和骨骼肌中19种氨基酸的水平。从而改善T2DM大鼠的氨基酸代谢紊乱。

更新日期：2020-10-11

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