Background and objective

To describe four cases of recurrent, fleeting corneal epithelial lesion, migratory serpiginous corneal epitheliopathy (MSCE).

Method

Description of cases, histopathology and discussion of treatment outcome.

Results

The study included 4 consecutive male patients; mean age was 21.25 years. Only one eye was affected. The common symptoms were irritation and tearing. Typical interpalpebral corneal lesion was a superficial greyish-white elevated corneal epithelium with stippled fluorescein staining in various geographic patterns. Corneal scrapings did not show any microorganisms and culture was negative; histopathology did not show corneal dysplasia. The lesions recurred within 1–3 weeks despite repeated scraping, application of a bandage contact lens, and a combination of topical antibiotics and lubricants. The recurrent lesion was of a different shape and eventually healed within 3–6 months without scarring.

Conclusion

We describe a possibly new entity, unilateral migratory serpiginous corneal epitheliopathy (MSCE) affecting young males, with inconspicuous inflammation. Etiology is not known and usually takes several months to heal after repeated epithelial debridement.

中文翻译：

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迁徙性锯齿状角膜上皮病（MSCE）-详细4例。

背景和目标

描述4例复发性转瞬即逝的角膜上皮病变，迁徙性锯齿状角膜上皮病变（MSCE）。

方法

病例描述，组织病理学和治疗结果讨论。

结果

该研究包括4名连续的男性患者。平均年龄为21.25岁。仅一只眼睛受到了影响。常见的症状是刺激和流泪。典型的睑间角膜病变是浅灰色白色的角膜上皮升高，并在各种地理模式下点缀了荧光素染色。角膜刮屑未显示任何微生物，培养阴性。组织病理学未见角膜发育不良。尽管反复刮擦，使用绷带隐形眼镜并结合使用局部抗生素和润滑剂，病变仍在1-3周内复发。复发性病变的形状不同，最终在3至6个月内愈合而无疤痕。

结论

我们描述了一种可能的新实体，单侧迁徙性锯齿状角膜上皮病（MSCE），其影响年轻的男性，并具有不起眼的炎症。病因不明，通常在反复上皮清创后需要几个月的时间才能治愈。