Background

Gastroesophageal reflux disease (GERD) may cause airway symptoms and some airway diseases exacerbate GERD symptoms. Asthma and allergic rhinitis (AR) have been identified as united airway disease because of their similar epidemiology and pathophysiology. Asthma has been considered a risk factor to develop GERD. However, the association between AR and GERD is not clear. We tried to investigate whether AR could increase the development of GERD.

Methods

Children diagnosed as AR without a prior history of GERD were conducted from the National Health Insurance Research Database between 2000 and 2005. After propensity score matching, we enrolled 36,588 children with AR and 36,588 non-AR children as the controls. Cox regression models were adopted to calculate the hazard ratio (HR) of GERD.

Results

AR children had a significantly increased risk of GERD than non-AR children (adjusted HR 1.91, 95% CI = 1.73–2.11, p < 0.001), especially in the age less than 6 years old (adjusted HR 2.68, 95% CI = 1.64–4.38, p < 0.001). The risk factor related to increased risk of GERD including age, gender, and chronic sinusitis.

Conclusion

AR is a risk factor associated with the development of GERD in children.

中文翻译：

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过敏性鼻炎是儿童胃食管反流病发展的关键因素

背景

胃食管反流病 (GERD) 可能会导致气道症状，一些气道疾病会加剧 GERD 症状。哮喘和过敏性鼻炎 (AR) 已被确定为联合气道疾病，因为它们具有相似的流行病学和病理生理学特征。哮喘被认为是发展 GERD 的危险因素。然而，AR 和 GERD 之间的关联尚不清楚。我们试图调查 AR 是否可以增加 GERD 的发展。

方法

在 2000 年至 2005 年期间，从国家健康保险研究数据库中对没有 GERD 病史的被诊断为 AR 的儿童进行了研究。在倾向得分匹配后，我们招募了 36,588 名 AR 儿童和 36,588 名非 AR 儿童作为对照。采用Cox回归模型计算GERD的风险比（HR）。

结果

AR 儿童的 GERD 风险显着高于非 AR 儿童（调整后 HR 1.91, 95% CI = 1.73–2.11, p < 0.001），尤其是在 6 岁以下（调整后 HR 2.68, 95% CI = 1.64–4.38，p < 0.001）。与 GERD 风险增加相关的风险因素包括年龄、性别和慢性鼻窦炎。

结论

AR是与儿童GERD发展相关的危险因素。