Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-08-18 , DOI: 10.1007/s13659-020-00261-1 Li Zhang 1 , Peng-Hui Yuan 1 , De-Zhi Yang 1 , Yan-Cai Bi 2 , Bin Su 2 , Bao-Xi Zhang 1 , Fu-Qing Wang 3 , Yang Lu 1 , Guan-Hua Du 4
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Betulin (BE) can be obtained from many plants, such as those belonging Betulaceae family, and pharmacological investigations showed its notable biological properties and good potential for food and pharmaceutical development. We investigated the homogeneity, stability, purity, and uncertainty of a newly certified reference material (CRM) of BE. The certified purity value for the CRM of BE was 99.56% with an extended uncertainty of 0.07% (k = 2, P = 0.95), as determined by differential scanning calorimetry (DSC). In this study, DSC was used for the first time for purity determination of BE. Given its high accuracy, precision, and reproducibility, DSC can be used as an alternative technique for purity determination of CRMs in the pharmaceutical and food industry.
Graphic abstract
中文翻译：
DSC对CRM桦木素的纯度和不确定性研究。
桦木素（BE）可以从许多植物中获得，例如属于桦木科的植物，药理研究表明其具有显着的生物学特性，在食品和药物开发中具有良好的潜力。我们研究了新认证的BE参照材料（CRM）的均质性，稳定性，纯度和不确定性。经差示扫描量热法（DSC）测定，BE的CRM的认证纯度值为99.56％，扩展不确定度为0.07％（k = 2，P = 0.95）。在这项研究中，DSC首次用于BE的纯度测定。鉴于其高准确性，精密度和可重复性，DSC可以用作制药和食品行业中CRM纯度测定的替代技术。
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