The construction of effective and safe theranostics was very important to realize tumor diagnosis and treatment simultaneously. Photothermal therapy had obtained great attention due to its remarkable capability of both cancer treatment and biosecurity. Molybdenum disulfide (MoS2) nanoflakes have shown excellent photothermal conversion efficiency, which were explored to photothermal therapy. However, MoS2 nanoflakes would decrease or quench the intensity of fluorescence when the MoS2 nanoflakes directly incorporated with fluorescence dyes to construct bioimaging theranostic systems. In this work, MoS2 nanoflakes embedded into MSNs to construct photothermal nanomaterials, which realized the nanoparticle size controllable. Fluorescein isothiocyanate (FITC) conjugated with mesoporous silica nanoparticles via amide bonds for bioimaging. It was more stable than physical absorption. As expected, the as-prepared FITC–MoS2 MSNs possessed photothermal effect, fluorescence stability and photostability. FITC–MoS2 MSNs were quickly taken up by HepG2 cells. Meanwhile, the HepG2 cells could be efficiently ablated under the 808 nm near-infrared laser irradiation. These results proved that we successfully constructed multifunctional MSNs for tumor theranostics. It also provided a potentially common nanoplatform for theranostic of biomedical applications.

中文翻译：

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介孔二氧化硅纳米粒子结合 MoS2 和 FITC 用于癌细胞的荧光成像和光热治疗

构建有效、安全的治疗诊断学对于实现肿瘤诊断与治疗同步进行至关重要。光热疗法因其在癌症治疗和生物安全方面的卓越能力而备受关注。二硫化钼 (MoS2) 纳米薄片显示出优异的光热转换效率，已被用于光热疗法。然而，当 MoS2 纳米薄片直接与荧光染料结合以构建生物成像治疗诊断系统时，MoS2 纳米薄片会降低或淬灭荧光强度。在这项工作中，MoS2 纳米薄片嵌入到 MSN 中构建光热纳米材料，实现了纳米颗粒尺寸可控。异硫氰酸荧光素 (FITC) 通过酰胺键与介孔二氧化硅纳米粒子结合用于生物成像。它比物理吸收更稳定。正如预期的那样，所制备的 FITC-MoS2 MSNs 具有光热效应、荧光稳定性和光稳定性。FITC-MoS2 MSNs 很快被 HepG2 细胞吸收。同时，在 808 nm 近红外激光照射下，HepG2 细胞可以被有效消融。这些结果证明我们成功构建了用于肿瘤治疗的多功能 MSN。它还为生物医学应用的治疗诊断提供了一个潜在的通用纳米平台。这些结果证明我们成功构建了用于肿瘤治疗的多功能 MSN。它还为生物医学应用的治疗诊断提供了一个潜在的通用纳米平台。这些结果证明我们成功构建了用于肿瘤治疗的多功能 MSN。它还为生物医学应用的治疗诊断提供了一个潜在的通用纳米平台。