当前位置: X-MOL 学术J. Occup. Health › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Occupational exposure limits for ethyl benzene, dimethyl terephthalate and hydrogen fluoride, and carcinogenicity and reproductive toxicant classifications
Journal of Occupational Health ( IF 2.6 ) Pub Date : 2020-01-01 , DOI: 10.1002/1348-9585.12151
, Atsuko Araki 1 , Kenichi Azuma 2 , Ginji Endo 3 , Yoko Endo 4 , Tetsuhito Fukushima 5 , Kunio Hara 6 , Hajime Hori 6 , Masayoshi Ichiba 7 , Tatsuya Ishitake 8 , Gaku Ichihara 9 , Akiyoshi Ito 6 , Yuki Ito 10 , Satoko Iwasawa 11 , Takeyasu Kakamu 5 , Michihiro Kamijima 10 , Kanae Karita 12 , Takahiko Katoh 13 , Toshio Kawai 14 , Toshihiro Kawamoto 3 , Reiko Kishi 1 , Shinji Kumagai , Yukinori Kusaka 15 , Muneyuki Miyagawa 16 , Hiroyuki Miyauchi 6 , Yasuo Morimoto 6 , Kasuke Nagano 17 , Hisao Naito 18 , Tamie Nakajima 19 , Makiko Nakano 20 , Tetsuo Nomiyama 21 , Hirokazu Okuda 22 , Masayuki Okuda 23 , Kazuyuki Omae 20 , Kazuhiro Sato 15 , Tomotaka Sobue 24 , Yasushi Suwazono 25 , Toru Takebayashi 20 , Tatsuya Takeshita 26 , Teruomi Tsukahara 21 , Masashi Tsunoda 11 , Jun Ueyama 27 , Yumi Umeda 22 , Kenya Yamamoto 28 , Yuko Yamano , Takenori Yamauchi , Eiji Yano 16
Affiliation  

Ethylbenzene [CAS No. 100-41-4] is a colorless liquid (boiling point 136.2°C, vapor pressure 1.27 kPa [25°C]) that is used as a raw material in the manufacture of stylene monomer, plastic, and rubber, and is a component of mixed xylene. This chemical was recommended at 100 ppm (430 mg/m3) for OEL-M in 1978, and revised at 50 ppm (217 mg/m3) and categorized Group 2B for class of carcinogenicity in 2001, and classified Group 2 as a reproductive toxicant in 2014. The JSOH reevaluated the occupational exposure limits (OEL) by examining subsequent reports this time, and proposed 20 ppm as OEL-M for ethylbenzene based on significant hearing loss in workers exposed to 30 ppm and noise in comparison with workers exposed to only nose,1 significant loss of outer hair cell of cochlear nerve at concentrations ≧200 ppm in 13 weeks inhalation study (0, 200, 400, 600, 800 ppm) in SD rats,2 and significant increase of auditory threshold ≧400 ppm in 5 days inhalation study (0, 300, 400, 550 ppm) in WAG/ Rij rats.3 Skin absorption notation is indicated, and classifications of carcinogenic (Group 2B) and reproductive toxicant (Group 2) remain the same. Dimethyl terephthalate [CAS No. 120-61-6] is white flakes (melting point 140°C, boiling point 288°C), and used as a material in the manufacture of polybuthylene terephtharate, film, polyester fiber. The JSOH proposed 8 mg/m3 as OEL-M for dimethyl terephthalate based on the results of animal experiment.4 Nose rubbing, preening, and blinking were found at the concentration of 86.4 mg/m3, but not at that of 16.5 mg/m3 in male LongEvans rats for 5 days 4-hour inhalation exposures per week for 58 days. Hydrogen fluoride [CAS No. 7664-39-3] is colorless corrosive gas and/or fume (melting point − 83°C, boiling point 20°C, vapor pressure 122 kPa [25°C]). It is used as a raw material of fluorine compounds, alkylating agent, and etching agent for glass and silica. The OEL-Ceiling, defined as the reference value to the maximal exposure concentration of the substance during a working day at or below which adverse health effects do not appear in most workers, of 3.0 ppm (2.5 mg/m3) is proposed based on the increased symptom scores from upper airways of human volunteer experiments.5,6 Symptoms in upper airways in human volunteers exposed to 2.5-5.2 mg/m3 were significantly increased compared to those exposed to 0.2-0.6 and 0.7-2.4 mg/ m3. In another human volunteer experiment, five volunteers suffered face flush at 5 days 6-hour exposures per week during 10-50 days. Skin absorption notation is indicated.

中文翻译:

乙苯、对苯二甲酸二甲酯和氟化氢的职业接触限值、致癌性和生殖毒物分类

乙苯 [CAS No. 100-41-4] 是一种无色液体(沸点 136.2°C,蒸气压 1.27 kPa [25°C]),用作制造苯乙烯单体、塑料和橡胶的原料,是混合二甲苯的成分。该化学品于 1978 年被推荐为 100 ppm (430 mg/m3) 用于 OEL-M,并在 2001 年修订为 50 ppm (217 mg/m3) 并在 2001 年将其归类为致癌性类别 2B,并将组 2 归类为生殖毒物2014 年,JSOH 通过审查后续报告重新评估了职业接触限值 (OEL),并根据与仅接触 30 ppm 和噪音的工人相比,暴露于 30 ppm 和噪音的工人听力显着受损,建议将 20 ppm 作为乙苯的 OEL-M鼻子,1 在 13 周吸入研究中浓度≥ 200 ppm 时,耳蜗神经外毛细胞显着丧失(0、200、400、600, 800 ppm) 在 SD 大鼠中,2 和听觉阈值显着增加 ≥ 400 ppm 在 5 天吸入研究中(0、300、400、550 ppm)在 WAG/Rij 大鼠中。3致癌物(第 2B 组)和生殖毒物(第 2 组)保持不变。对苯二甲酸二甲酯 [CAS No. 120-61-6] 为白色薄片(熔点 140°C,沸点 288°C),用作制造聚对苯二甲酸丁二醇酯、薄膜、聚酯纤维的原料。根据动物实验结果,JSOH 建议对苯二甲酸二甲酯的 OEL-M 为 8 mg/m3。4 在 86.4 mg/m3 的浓度下发现揉鼻子、梳理和眨眼,但在 16.5 mg/m3 时没有发现在雄性 LongEvans 大鼠中进行 5 天,每周 4 小时吸入暴露,持续 58 天。氟化氢 [CAS No. 7664-39-3] 是无色腐蚀性气体和/或烟雾(熔点 - 83°C,沸点 20°C,蒸气压 122 kPa [25°C])。用作氟化合物的原料、烷化剂、玻璃和二氧化硅的蚀刻剂。OEL 上限,定义为该物质在一个工作日内的最大暴露浓度的参考值,在该浓度下,大多数工人不会对健康产生不利影响,建议基于 3.0 ppm (2.5 mg/m3)人类志愿者实验的上呼吸道症状评分增加。5,6 与暴露于 0.2-0.6 和 0.7-2.4 mg/m3 的志愿者相比,暴露于 2.5-5.2 mg/m3 的人类志愿者的上呼吸道症状显着增加。在另一项人类志愿者实验中,五名志愿者在 10-50 天内每周暴露 5 天 6 小时出现面部潮红。
更新日期:2020-01-01
down
wechat
bug