IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and renal failure. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the immunoproteasome probably plays an important role in IgAN. The immunoproteasome is a proteasome variant that is expressed when cells are stressed or receive inflammatory signals. While immunoproteasome is suggested to be mainly involved in major histocompatibility complex-I (MHC-I) antigen presentation, recent studies indicate that it may assert broad functions in trafficking events that activate both innate and adaptive immunity. In this review, we first summarize new insights into its functions in immunity, and discuss how it underlies its associations with IgAN. We also highlight its potential as a therapeutic target for the future.

中文翻译：

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IgA 肾病中的免疫蛋白酶体：最新技术和未来展望。

IgA 肾病 (IgAN) 是慢性肾病和肾功能衰竭的主要原因。IgAN 的确切发病机制尚未明确，但一些遗传研究导致了一项新发现，即免疫蛋白酶体可能在 IgAN 中起重要作用。免疫蛋白酶体是一种蛋白酶体变体，当细胞受到压力或接收炎症信号时会表达。虽然免疫蛋白酶体被认为主要参与主要组织相容性复合体-I (MHC-I) 抗原呈递，但最近的研究表明它可能在激活先天免疫和适应性免疫的贩运事件中发挥广泛的作用。在这篇综述中，我们首先总结了对其免疫功能的新见解，并讨论了它如何成为其与 IgAN 关联的基础。我们还强调了它作为未来治疗目标的潜力。