Complex decorrelation-based OCT angiography (OCTA) has the potential for monitoring hemodynamic activities in a label-free, high-resolution, and quantitative manner. To improve the measurement dynamic range and uncertainty of blood flow, an adaptive spatial-temporal (ST) kernel was proposed for decorrelation estimation and it was validated through a theoretical simulation and experimental measurements. The ensemble size in the decorrelation computation was effectively enlarged by collecting samples of the phasor pair in both the spatial and temporal dimensions. The spatial sub-kernel size was adaptively changed to suppress the influence of bulk motion in the temporal dimension by solving a maximum entropy model. Using the flow phantom, it was observed that the decorrelation dynamic range presented an increase of ~49% and the uncertainty exhibited a decrease of ~40% and ~38% in the saturation and background limits, respectively. In monitoring the stimulus-evoked hemodynamic response, the extended dynamic range enabled an improvement of ~180% in the separability between different stimulation modes. Furthermore, the suppressed uncertainty and motion artifacts allowed a reliable temporal analysis of the hemodynamic response. The proposed adaptive ST-kernel will greatly promote the development of decorrelation-based quantitative OCTA in hemodynamic studies.

中文翻译：

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改进的基于去相关的OCT血管造影的自适应时空核在监测刺激诱发的血流动力学反应。

基于复杂去相关的OCT血管造影术（OCTA）具有以无标记，高分辨率和定量方式监测血液动力学活动的潜力。为了提高测量动态范围和血流的不确定性，提出了一种自适应空时（ST）核用于去相关估计，并通过理论仿真和实验测量对其进行了验证。通过在空间和时间维度上收集相量对的样本，可以有效地扩大去相关计算中的合奏大小。通过求解最大熵模型，自适应更改空间子内核的大小，以抑制整体运动在时间维度上的影响。使用流幻影，观察到，去饱和动态范围在饱和度和背景范围内分别增加了约49％和不确定性，分别降低了约40％和38％。在监测刺激引起的血流动力学反应时，扩展的动态范围使不同刺激模式之间的可分离性提高了约180％。此外，抑制的不确定性和运动伪影允许对血液动力学反应进行可靠的时间分析。提出的自适应ST核将极大地促进基于去相关的定量OCTA在血液动力学研究中的发展。扩展的动态范围使不同刺激模式之间的可分离性提高了约180％。此外，抑制的不确定性和运动伪影允许对血液动力学反应进行可靠的时间分析。提出的自适应ST核将极大地促进基于去相关的定量OCTA在血液动力学研究中的发展。扩展的动态范围使不同刺激模式之间的可分离性提高了约180％。此外，抑制的不确定性和运动伪影允许对血液动力学反应进行可靠的时间分析。提出的自适应ST核将极大地促进基于去相关的定量OCTA在血液动力学研究中的发展。