Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R. A total of 4294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis. Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04–1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01–3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04–1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in overweight men. This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

中文翻译：

---

韩国男性和女性中MC4R（rs17782313）与糖尿病和心血管疾病的关联。

糖尿病主要由空腹血糖水平评估。几项研究报告说，空腹血糖水平和心血管疾病与MC4R有关。共有4294位受试者参加了这项研究。在4294名受试者中，有1810名患有心血管疾病。我们使用了多元线性回归模型和多元逻辑回归分析。调整年龄，性别和BMI后，具有TC / CC基因型的个体患糖尿病的风险比具有TT基因型的个体高1.29倍（OR，1.29； 95％CI，1.04-1.60）。对于健康受试者，该关联在女性中显着（OR，1.99； 95％CI，1.01-3.93）。调整年龄，性别和体重指数后，具有TC / CC基因型的男性患心血管疾病的风险比具有TT基因型的男性高1.21倍（OR，1.21； 95％CI，1.04-1.41）。瘦男人的MC4R与心血管疾病之间的关系更强（OR，1.40； 95％CI，1.12-1.74，p = 0.0028），而超重的男人更是如此。这项研究表明，MC4R中的rs17782313 SNP与糖尿病有关，而SNP也与瘦男人的心血管疾病有关。