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A hairy tale: SIRT7 safeguards skin stem cells during aging.
The EMBO Journal ( IF 9.4 ) Pub Date : 2020-08-16 , DOI: 10.15252/embj.2020106294
Matthew Simon 1 , Stephan Emmrich 1 , Andrei Seluanov 1, 2 , Vera Gorbunova 1, 2
Affiliation  

Stem cell regulation during both normal development and aging has become one of the fastest growing topics in biology. Here, new work by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and highlights how SIRT7, a member of the sirtuin family of protein deacylases and mono‐ADP ribosylases, protects adult hair follicle stem cells from aging by ensuring their hair cycle progression.

中文翻译:

一个毛骨悚然的故事:SIRT7 在衰老过程中保护皮肤干细胞。

正常发育和衰老过程中的干细胞调节已成为生物学中发展最快的主题之一。在这里,Li等人(2020) 的新工作深入了解了上皮皮肤干细胞内的衰老过程,并强调了 SIRT7(蛋白质脱酰酶和单 ADP 核糖基化酶的 Sirtuin 家族的成员)如何保护成年毛囊干细胞免于衰老通过确保他们的头发周期进展。
更新日期:2020-09-15
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