Mutations in several genes encoding for lysosomal proteins are involved in Parkinson's disease (PD). In this issue, Herbst et al (2020) show that PD‐related leucine‐rich repeat kinase 2 (LRRK2) is activated in response to pathogen or membranolytic drug‐induced damage of phagolysosomes and lysosomes in macrophages, and regulates endolysosomal homeostasis by controlling the balance between membrane repair and degradation.

中文翻译：

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LRRK2 可以拯救受损的内膜。


编码溶酶体蛋白的多个基因的突变与帕金森病（PD）有关。在本期中，Herbst等人(2020) 表明，PD 相关的富含亮氨酸重复激酶 2 (LRRK2) 在病原体或溶膜药物引起的巨噬细胞吞噬溶酶体和溶酶体损伤时被激活，并通过控制内溶酶体稳态来调节内溶酶体稳态。膜修复和降解之间的平衡。