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Thermoresponsive Self-Immolative Polyglyoxylamides.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-08-17 , DOI: 10.1021/acs.biomac.0c00899 Amir Rabiee Kenaree 1 , Quinton E A Sirianni 1 , Kyle Classen 1 , Elizabeth R Gillies 1, 2
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-08-17 , DOI: 10.1021/acs.biomac.0c00899 Amir Rabiee Kenaree 1 , Quinton E A Sirianni 1 , Kyle Classen 1 , Elizabeth R Gillies 1, 2
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Thermoresponsive polymers with lower critical solution temperatures (LCSTs) are of significant interest for a wide range of applications from sensors to drug delivery vehicles. However, the most widely investigated LCST polymers have nondegradable backbones, limiting their applications in vivo or in the environment. Described here are thermoresponsive polymers based on a self-immolative polyglyoxylamide (PGAM) backbone. Poly(ethyl glyoxylate) was amidated with six different alkoxyalkyl amines to afford the corresponding PGAMs, and their cloud point temperatures (Tcps) were studied in water and buffer. Selected examples with promising thermoresponsive behavior were also studied in cell culture media, and their aggregation behavior was investigated using dynamic light scattering (DLS). The Tcps were effectively tuned by varying the pendent functional groups. These polymers depolymerized end-to-end following the cleavage of end-caps from their termini. The structures and aggregation behavior of the polymers influenced their rates of depolymerization, and, in turn, the depolymerization influenced their Tcp. Cell culture experiments indicated that the polymers exhibited low toxicity to C2C12 mouse myoblast cells. This interplay between LCST and depolymerization behavior, combined with low toxicity, makes this new class of polymers of particular interest for biomedical applications.
中文翻译：
热响应性自焚聚乙二酰胺。
具有较低临界溶液温度（LCST）的热敏聚合物对于从传感器到药物输送工具的广泛应用具有重大意义。但是，研究最广泛的LCST聚合物具有不可降解的主链，限制了它们在体内或环境中的应用。在此描述的是基于自消旋聚乙二酰胺（PGAM）主链的热敏聚合物。将聚乙醛酸乙酯与六种不同的烷氧基烷基胺酰胺化，得到相应的PGAM，以及它们的浊点温度（T cp在水和缓冲液中进行了研究。在细胞培养基中还研究了具有希望的热响应行为的选定实例，并使用动态光散射（DLS）研究了它们的聚集行为。所述Ť CP小号得到有效通过改变悬挂官能团调谐。这些聚合物在末端被其末端裂解后端对端解聚。聚合物的结构和聚集行为影响其解聚速率，进而解聚影响其T cp。细胞培养实验表明，该聚合物对C2C12小鼠成肌细胞具有低毒性。LCST与解聚行为之间的相互作用以及低毒性使得这种新型的聚合物在生物医学应用中特别受关注。
更新日期：2020-09-14
中文翻译：
热响应性自焚聚乙二酰胺。
具有较低临界溶液温度（LCST）的热敏聚合物对于从传感器到药物输送工具的广泛应用具有重大意义。但是，研究最广泛的LCST聚合物具有不可降解的主链，限制了它们在体内或环境中的应用。在此描述的是基于自消旋聚乙二酰胺（PGAM）主链的热敏聚合物。将聚乙醛酸乙酯与六种不同的烷氧基烷基胺酰胺化，得到相应的PGAM，以及它们的浊点温度（T cp在水和缓冲液中进行了研究。在细胞培养基中还研究了具有希望的热响应行为的选定实例，并使用动态光散射（DLS）研究了它们的聚集行为。所述Ť CP小号得到有效通过改变悬挂官能团调谐。这些聚合物在末端被其末端裂解后端对端解聚。聚合物的结构和聚集行为影响其解聚速率，进而解聚影响其T cp。细胞培养实验表明，该聚合物对C2C12小鼠成肌细胞具有低毒性。LCST与解聚行为之间的相互作用以及低毒性使得这种新型的聚合物在生物医学应用中特别受关注。
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