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Synthesis, Characterization, and Antimicrobial Evaluation of Some New 1,4-Dihydropyridine Hybrid with 1,3,4-Thiadiazole
Polycyclic Aromatic Compounds ( IF 2.4 ) Pub Date : 2020-08-17
Sobhi M. Gomha, Zeinab A. Muhammad, Sami A. Al-Hussain, Magdi E. A. Zaki, Hassan M. Abdel-aziz

A synthesis of 2,2′-((2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbonyl)bis (hydrazin-2-yl-1-ylidene))bis(N-phenylpropanehydrazonoyl chloride) (3) and studying its examining its manufactured utilities as structure hinders for novel arrangement of bis-1,3,4-thiadiazole derivatives 6a–f, 9a,b, 11, and 12 in one stage technique with great yields by reaction with different hydrazinecarbodithioate derivatives 4a–f and 7a,b. The structure of the products was built up on various analytical and spectroscopic informations. In addition, biological assessment of the acquired compounds as antibacterial and antifungal agents was accomplished and the outcomes got investigating the high potency of some of the tested compounds compared with the employed standard bactericides and fungicides. Moreover, the minimum inhibitory concentration (MIC) of the tested compounds was determined and therefore the results obtained exploring the high efficiency of a number of the tested compounds against all the tested microorganisms.



中文翻译:

1,3,4-噻二唑与某些新型1,4-二氢吡啶杂化物的合成,表征及抗菌性能评价

2,2'-(((2,6-二甲基-4-苯基-1,4-二氢吡啶-3,5-二羰基)双(肼基-2-基-1-亚烷基))双(N-苯基丙烷肼基酰基)的合成氯化物)(3)并研究其作为结构障碍的工业实用性,该结构阻碍了-1,3,4-噻二唑衍生物6a-f,9a,b,1112的一步反应,反应收率很高。与不同的肼二硫代肼衍生物4a-f7a,b。产品的结构建立在各种分析和光谱信息上。此外,对获得的化合物作为抗菌剂和抗真菌剂进行了生物学评估,结果研究了一些测试化合物与所用标准杀菌剂和杀真菌剂相比具有的高效力。此外,确定了被测化合物的最小抑菌浓度(MIC),因此获得了探索多种被测化合物对所有被测微生物的高效率所获得的结果。

更新日期:2020-08-17
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